The behavior of a novel formulation (Nanoparticles) for targetted drug delivery in a living body is a complex phenomenon dictated by a host of individual and interrelated systems. Our team works on preclinical in vivo pharmacokinetic studies for the optimization of NDDS formulation.
Pharmacokinetic (PK) and pharmacodynamic (PD) information from the scientific basis of modern pharmacotherapy. Pharmacokinetics describes the drug concentration-time courses in body fluids resulting from the administration of a certain drug dose, pharmacodynamics the observed effect resulting from a certain drug concentration. The rationale for PK/PD-modelling is to link pharmacokinetics and pharmacodynamics in order to establish and evaluate dose-concentration-response relationships and subsequently describe and predict the effect-time courses resulting from a drug dose.
Animal infection models in the pharmacokinetic/pharmacodynamic (PK/PD) evaluation of antimicrobial therapy serve an important role in preclinical assessments of new antibiotics, dosing optimization for those that are clinically approved, and setting or confirming susceptibility breakpoints. The goal of animal model studies is to mimic the infectious diseases seen in humans to allow for robust PK/PD studies to find the optimal drug exposures that lead to therapeutic success.
Our capabilities in pharmacokinetics include early exploratory, investigative or screening studies, juvenile studies, disease model studies and formal studies that support a regulatory submission.
The PK/PD index and target drug exposures obtained in validated animal infection models are critical components in optimizing dosing regimen design in order to maximize efficacy while minimizing the cost and duration of clinical trials.
Established Animal models
The purpose of toxicity studies is, ultimately, non-clinical safety evaluation through characterization.More
Preclinical research offers the evaluation of potential therapeutic interventions in animal models.More
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