Our Studies

In vivo Efficacy

In vivo efficacy studies is the study of the biological effects of a drug in a complex living organism and is used to observe the complex physiological effects of a drug. Our scientist working on early research and proof-of-concept (POC) pharmacological studies in relevant animal models of human diseases to efficacy evaluations. Our scientific team has wide experience with numerous disease models and assays, as well as efficient in developing new models to meet the specific needs of a particular compound or discovery program. We have established various models to evaluate the efficacy of target molecule in various pain, inflammation, neuropharmacological studies, wound healing and metabolic disorders, etc. Which includes:

Neuropathic pain

  • Diabetic neuropathy
  • Chronic Constriction Injury
  • Spinal Nerve Ligation
  • Spared Nerve Injury
  • Sciatic Nerve Ligation

Inflammatory pain

  • Formalin-induced Pain (Acute)
  • Freund's Adjuvant-induced Hyperalgesia (Chronic)
  • Carrageenan-induced Hyperalgesia
  • MIA/MMT-induced OA

Mechanical & Thermal Nociception

  • Rat Pinch Model
  • Tail Flick
  • Hot plate

Visceral pain

  • Acetic Acid-induced Writhing

Acute inflammation

  • Carrageenan-induced Paw Edema
  • Croton oil-induced mouse ear edema
  • Carrageenan-Air Pouch Inflammation
  • Delayed Type Hypersensitivity

Chronic inflammation

  • Croton pellet induced granuloma
  • Collagen-induced Arthritis
  • Freund’s adjuvant-induced poly-arthritis
  • Formaldehyde-induced arthritis
  • Sodium urate-induced gout

Learning and memory

  • Morris water maze
  • Elevated plus maze
  • Contextual Fear Conditioning (CFC) test
  • Novel Object Recognition Test (NORT)
  • Novel Environment Recognition Test (NERT)

Stress and Depression

  • Forced Swim Test
  • Tail suspension testings
  • Chronic unpredictable mild stress
  • Chronic Fatigue Syndrome


  • Stress-induced Hyperthermia


  • MPTP induced Parkinsonism for Neuro-degeneration

Wound Healing Models

  • Excision & Incision wound
  • Diabetes wound
  • Burn Wound

Metabolic disorders

  • Streptozotocin-induced T1 Diabetes
  • Alloxan-induced T1 Diabetes
  • HFD induced T2 Diabetes

Other Models

  • Locomotor Activity test
  • Motor Liability test in rat with Rotarod


Toxicity studies

The purpose of toxicity studies is, ultimately, non-clinical safety evaluation through characterization.

PK/PD Studies

Our capabilities in pharmacokinetics include early exploratory, investigative or screening studies.

Pre-Clinical and Toxicology

Preclinical research offers the evaluation of potential therapeutic interventions in animal models.


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