Our Studies
In vivo Efficacy
Studies
In vivo efficacy studies is the study of the biological effects of a drug in a complex living organism and is used to observe the complex physiological effects of a drug. Our scientist working on early research and proof-of-concept (POC) pharmacological studies in relevant animal models of human diseases to efficacy evaluations. Our scientific team has wide experience with numerous disease models and assays, as well as efficient in developing new models to meet the specific needs of a particular compound or discovery program. We have established various models to evaluate the efficacy of target molecule in various pain, inflammation, neuropharmacological studies, wound healing and metabolic disorders, etc. Which includes:
Neuropathic pain
- Diabetic neuropathy
- Chronic Constriction Injury
- Spinal Nerve Ligation
- Spared Nerve Injury
- Sciatic Nerve Ligation
Inflammatory pain
- Formalin-induced Pain (Acute)
- Freund's Adjuvant-induced Hyperalgesia (Chronic)
- Carrageenan-induced Hyperalgesia
- MIA/MMT-induced OA
Mechanical & Thermal Nociception
- Rat Pinch Model
- Tail Flick
- Hot plate
Visceral pain
- Acetic Acid-induced Writhing
Acute inflammation
- Carrageenan-induced Paw Edema
- Croton oil-induced mouse ear edema
- Carrageenan-Air Pouch Inflammation
- Delayed Type Hypersensitivity
Chronic inflammation
- Croton pellet induced granuloma
- Collagen-induced Arthritis
- Freund’s adjuvant-induced poly-arthritis
- Formaldehyde-induced arthritis
- Sodium urate-induced gout
Learning and memory
- Morris water maze
- Elevated plus maze
- Contextual Fear Conditioning (CFC) test
- Novel Object Recognition Test (NORT)
- Novel Environment Recognition Test (NERT)
Stress and Depression
- Forced Swim Test
- Tail suspension testings
- Chronic unpredictable mild stress
- Chronic Fatigue Syndrome
Anxiety
- Stress-induced Hyperthermia
Parkinsonism
- MPTP induced Parkinsonism for Neuro-degeneration
Wound Healing Models
- Excision & Incision wound
- Diabetes wound
- Burn Wound
Metabolic disorders
- Streptozotocin-induced T1 Diabetes
- Alloxan-induced T1 Diabetes
- HFD induced T2 Diabetes
Other Models
- Locomotor Activity test
- Motor Liability test in rat with Rotarod
DISCOVER OUR AREAS OF WORK
Toxicity studies
The purpose of toxicity studies is, ultimately, non-clinical safety evaluation through characterization.
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PK/PD Studies
Our capabilities in pharmacokinetics include early exploratory, investigative or screening studies.
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Pre-Clinical and Toxicology
Preclinical research offers the evaluation of potential therapeutic interventions in animal models.
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