Dr. Dilip Kumar Roy

Head Scientist | Preclinical Research


“In modern pharmacology, it's so clear that even if you have a fixed dose of a drug, the individuals respond very differently to one and the same dose”

“In modern pharmacology, it's so clear that even if you have a fixed dose of a drug, the individuals respond very differently to one and the same dose”


Years at VMRC




Awards & Honors

Efficacy and safety studies are a very important tool in drug discovery and development. It may be for the new molecule or novel formulation of an existing molecule. Only the in-vitro test is not sufficient to evaluate the efficacy of any compound. Testing in the animal model gives a true picture of efficacy in a more complex biological system as there are remarkable anatomical and physiological similarities between humans and animals. On the other hand, safety is more important before initiation of human studies. Toxicity studies identify possible hazards of a test substance which may likely be produced after single and multiple uses. The information collected from these studies is vital so that safe human testing can begin. Based on preclinical trials, no-observed-adverse-effect levels (NOAELs) on drugs are established, which are used to determine initial phase 1 clinical trial dosage levels on a mass drug per mass patient basis.

PK/PD studies in animals vital for determining dose and dosing interval of antibiotic. Dosing of antibiotic is determined by correlating exposure and response relationship (PK/PD) in human against drug-susceptible and resistant bacteria and this PK/PD index is determined by animal studies. We have completed several experiments on animal models for infectious disease (Thigh infection, lung infection and UT infection) and few are in pipeline ( Gonorrhoea, septicemia).

In vitro and In vivo preclinical pharmacodynamics, Pharmacokinetics, GLP Toxicity, Toxicokinetics, Biocompatibility studies, Immunogenicity studies of vaccine, PK/PD index determination for an antibiotic, PK/PD modeling, and simulation.

Anti-Inflammatory Activity Of Indian Black Tea (Sikkim Variety)
Pharmacological Research 51, 169–175.

Nag Chaudhuri, A.K., Karmakar, Sanmoy, Roy, Dilip Kumar, Pal, Siddhartah, Pal, Mintu And Sen, Tuhinadri (2005)

Pharmacological Studies On Indian Black Tea (Leaf Variety) In Acute And Chronic Inflammatory Conditions
Phytotherapy Research 22, 814–819.

Roy D.K., Mani Senthil Kumar K.T., Puia, Zothan, Karmakar S, Pal S, Samanta SK, Adhikari D, Sen T (2008)

Anti-Inflammatory Activity Of Acanthus ilicifolius
Journal of Ethnopharmacology 120, 7–12

Mani Senthil Kumar KT, Gorain B, Roy DK, Zothanpuia, Samanta SK, Pal M, Biswas P, Roy A, Adhikari D, Karmakar S, Sen T. (2008)

Gastro-Protective Role Of Acanthus ilicifolius – A Study To Unravel The Underlying Mechanism Of Anti-Ulcer Activity.
Scientia Pharmaceutica 80, 701–717

Mani Senthil Kumar, K. T., Puia, Zothan., Samanta, S.K., Barik, Rajiv, Dutta, Arnab, Gorian, Bapi, Roy, D. K., Adhikari, Dipan, Karmakar, Sanmoy and Sen, Tuhinadri. (2012)

Pharmacological And Biochemical Studies On Telescopium Telescopium
A Marine Mollusk From The Mangrove Regions Oriental Pharmacy and Experimental Medicine 8(4), 386-394.

Samanta, S.K., Adhikari, D., Karmakar, S., Dutta, A., Roy, A., Manisenthil, K.T., Roy, D., Vedasiromoni, J.R and Sen, T. (2008)

  • Jadavpur University, Kolkata Ph.D. -2007 (Pharmacy)
  • Jadavpur University,Kolkata PG- 2002 (Pharmacy)
  • Jadavpur University,Kolkata UG-1999(Pharmacy)
  • Senior Research Fellowship 2005-2005.
  • UGC Scholarship 2000-2002.
  • Innovative idea award for the year 2014-15.

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