Senior- Associate Scientist | Preclinical Research
Postdoc
“Research is to see what everybody else has seen, and to think what nobody else has thought.”
Years at VMRC
Publications
Awards & Honors
Presently our team is working on Stealth Targeted Nanoparticles (STN) design of nanocarriers for oral delivery of poorly bioavailable drugs especially antibiotics. Patients preferred oral route over intravenous route.
The route of administration and the duration of treatment are variables that influence the study outcome. Route of administration of any compound is an important part in a pre-clinical study which includes bioavailability, bioequivalence as well as biocompatibility. In preclinical studies, pharmacokinetic and pharmacodynamic factors play a vital role in the evaluation of any agents. Only when the metabolic profile and pharmacodynamic characteristics of a drug are understood can the most efficient testing protocol be designed for a particular agent. Due to metabolic differences and pharmacodynamic factors, different results may be obtained depending on whether drugs are administered orally or intravenously.
Preclinical research offers the evaluation of potential therapeutic interventions in an animal model of the disease. Candidates for entry into clinical trials can then be selected based on their effectiveness and safety in disease models. All drugs require data from various toxicological preclinical studies to support their potential safety in humans before clinical trials can begin.
Medicines can be of amazing benefit to human health, they can also be extremely dangerous if not researched and/or administered correctly. The thalidomide disaster is one of the darkest episodes in pharmaceutical research history. It caused thousands of babies worldwide to be born with malformed limbs due to lack of animal testing. The thalidomide tragedy gives us lessons for Drug Safety and Regulation requirements and inspired us to work in this area.
Sachdeva AK, Dharavath RN, Chopra K. (2019)
Sachdeva AK and Chopra K. (2015)
Sachdeva AK and Chopra K. (2015)
Chopra K, Bansal S, Sachdeva AK. (2016)
Sachdeva AK, Misra S, Pal Kaur I, Chopra K. (2014)
Sachdeva AK, Kuhad A, Chopra K. (2014)
Sachdeva AK, Kuhad A, Chopra K.(2011)
Sachdeva AK, Kuhad A, Tiwari V, Arora V, Chopra K.(2010)
Sachdeva AK, Kuhad A, Tiwari V, Chopra K.(2009)
Kuhad A, Sachdeva AK, Chopra K. (2009)
Chaudhary M , Kumar P, Kumar S, Sachdeva AK, M Vinoth Kumar. (2016)
Arora V, Sachdeva AK, Singh P, Baveja A, Chopra K, Kuhad A.
Sachdeva AK, Mishra S, Kaur IP, Chopra K.
Arora V, Kuhad A, Sachdeva AK and Kanwaljit Chopra
Sachdeva AK, Chopra K. (2015)
Sachdeva AK, Kuhad A, Chopra K. (2013)
Sachdeva AK, Kuhad A, Chopra K. (2014)
Sachdeva AK, Chopra K. (2015)
Sachdeva AK, Sethi R, Kuhad A, Chopra K. (2009)
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